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[Sar9] Substance P

Name
[Sar9] Substance P
Molecular structural formula
Purity
95%
CAS Number
77128-75-7
Formula
C64H100N18O13S1
MW
1361.66
Target
Neurokinin Receptor
Sequence
Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met-NH2
Sequence Shortening
RPKPQQFF-(NMe)G-LM-NH2
InChIKey
CMARLNZAQITWSL-UHFFFAOYSA-N
Solubility in water
≥ 50 mg/mL
References
[1]. Lieberman DN, et al. Substance P enhances NMDA channel function in hippocampal dentate gyrus granule cells. J Neurophysiol. 1998 Jul;80(1):113-9.
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[Sar9] Substance P is a potent and selective neurokinin (NK)-1 receptor agonist.

[Sar9]-Substance P acetate is a potent and selective neurokinin (NK)-1 receptor agonist. The effect of SP on progesterone metabolism was mimicked by the rNK1-specific agonist [Sar-9,Met(O2)11]-SP.